Chemical cross-linking coupled with mass spectrometry
Chemical cross-linking coupled with mass spectrometry（XL-MS）is an important technique for examining protein-protein interactions (PPIs). It uses cross-linking agents to Chemically cross-link proteins and their complexes that interact within a certain distance.
Chemical cross-linking coupled with mass spectrometry Advantage
- High throughput and fast analysis speed
- Can undergo intracellular cross-linking
- No need for special chemical labeling of proteins
- Cross-linking agents can covalently connect two or more interacting proteins and retain short-lived/weak interactions.
Description of Chemical cross-linking coupled with mass spectrometry
Chemical cross-linking coupled with mass spectrometry（XL-MS）is an important technique for examining protein-protein interactions (PPIs). It uses cross-linking agents to Chemically cross-link proteins and their complexes that interact within a certain distance. Then Mass spectrometry analyzes cross-linked peptides, depicts protein interaction networks, and identifies their sites of action. XL-MS can also be used in conjunction with other techniques, such as cryo-electron microscopy (cryo-EM) and X-ray crystal diffraction, for research on biological structures.
Service Process
Customers can send cross-linked samples or contact us to develop a cross-linking plan and send the samples. We will complete the entire process of enzyme digestion, peptide enrichment, mass spectrometry detection, data analysis, and deliver the experimental report.
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ChIP-seq
ChIP studies the interaction between DNA and proteins, and ChIP-seq is combined with next-generation sequencing to detect DNA sites in the genome that bind to specific transcription factors/histones, which is used to study the interaction between proteins and chromatin.
Genomics
Longlight has focused on molecular diagnosis and molecular biology, we has launched some NGS related instruments and reagent consumables, mainly Focused Ultrasonicator, been committed to promoting the development of genomics, to serve the human medical cause better.
Consumables and Kits
Longlight provides different types of precast agarose gel, nucleic acid scavenger, Qubit tube, nucleic acid extraction kits, and library preparation kits. In the meanwhile, all of these products can be widely used in basic scientific research, biopharmaceuticals and other application scenarios.
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