Cryo‐electron microscopy
Cryo‐electron microscopy (cryo‐EM) is a structural biological method that is used to determine the 3D structures of biomacromolecules. Its purpose is to observe the structure of the sample in its original state as close as possible.
Cryo‐electron microscopy Advantage
- The three-dimensional structure of macromolecular proteins can be obtained without crystallization and with a very small amount of sample required.
- The amorphous state ensures that electron beam detection will not cause interference to the sample imaging.
- Using electron tomography requires lower sample requirements than single particle analysis.
- Can resolve structures at atomic-level resolution (0.2-0.3 nm)
Description of Cryo‐electron microscopy
Cryo‐electron microscopy (cryo‐EM) is a structural biological method that is used to determine the 3D structures of biomacromolecules. Its purpose is to observe the structure of the sample in its original state as close as possible. It is especially suitable for samples containing water and is an important characterization tool for studying biological samples. Using the solution of sample in-situ freezing–electron tomography–three-dimensional reconstruction, we can obtain the 3D structure diagram of macromolecular biological samples, which is a great tool for studying protein structure. With the development of technology, the application scope of cryo-EM has been further expanded. In addition to common protein structure research, it can also be used to study special materials that are sensitive to electron beams and heat.
Service Process
Customers only need to send samples, and we will complete the sample preparation, sample imaging, three-dimensional reconstruction process, and issue an experimental result report.
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ChIP-seq
ChIP studies the interaction between DNA and proteins, and ChIP-seq is combined with next-generation sequencing to detect DNA sites in the genome that bind to specific transcription factors/histones, which is used to study the interaction between proteins and chromatin.
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Longlight has focused on molecular diagnosis and molecular biology, we has launched some NGS related instruments and reagent consumables, mainly Focused Ultrasonicator, been committed to promoting the development of genomics, to serve the human medical cause better.
Consumables and Kits
Longlight provides different types of precast agarose gel, nucleic acid scavenger, Qubit tube, nucleic acid extraction kits, and library preparation kits. In the meanwhile, all of these products can be widely used in basic scientific research, biopharmaceuticals and other application scenarios.
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